:root{--ts-bg: #ffffff;--ts-surface: #ffffff;--ts-surface-elevated: #f8fafc;--ts-surface-hover: #f1f5f9;--ts-border: #e2e8f0;--ts-border-strong: #cbd5e1;--ts-border-subtle: rgba(0, 0, 0, .04);--ts-text: #0f172a;--ts-text-secondary: #475569;--ts-text-muted: #64748b;--ts-text-disabled: #cbd5e1;--ts-accent: #d97706;--ts-accent-hover: #b45309;--ts-accent-dim: #92400e;--ts-accent-bg: rgba(217, 119, 6, .08);--ts-accent-bg-strong: rgba(217, 119, 6, .16);--ts-accent-border: rgba(217, 119, 6, .32);--ts-success: #16a34a;--ts-success-bg: rgba(22, 163, 74, .1);--ts-success-border: rgba(22, 163, 74, .3);--ts-warning: #ca8a04;--ts-warning-bg: rgba(202, 138, 4, .1);--ts-warning-border: rgba(202, 138, 4, .3);--ts-danger: #dc2626;--ts-danger-bg: rgba(220, 38, 38, .08);--ts-danger-border: rgba(220, 38, 38, .3);--ts-info: #2563eb;--ts-info-bg: rgba(37, 99, 235, .08);--ts-info-border: rgba(37, 99, 235, .3);--ts-font-sans: "IBM Plex Sans", system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;--ts-font-mono: "IBM Plex Mono", "JetBrains Mono", "SF Mono", Menlo, Consolas, monospace;--ts-text-2xs: 11px;--ts-text-xs: 12px;--ts-text-sm: 13px;--ts-text-base: 14px;--ts-text-md: 16px;--ts-text-lg: 18px;--ts-text-xl: 22px;--ts-text-2xl: 28px;--ts-text-3xl: 36px;--ts-text-4xl: 48px;--ts-text-5xl: 64px;--ts-weight-regular: 400;--ts-weight-medium: 500;--ts-weight-semibold: 600;--ts-weight-bold: 700;--ts-leading-tight: 1.2;--ts-leading-snug: 1.35;--ts-leading-normal: 1.5;--ts-leading-relaxed: 1.65;--ts-tracking-tight: -.01em;--ts-tracking-normal: 0;--ts-tracking-wide: .02em;--ts-tracking-caps: .06em;--ts-space-0: 0;--ts-space-1: 4px;--ts-space-2: 8px;--ts-space-3: 12px;--ts-space-4: 16px;--ts-space-5: 20px;--ts-space-6: 24px;--ts-space-8: 32px;--ts-space-10: 40px;--ts-space-12: 48px;--ts-space-16: 64px;--ts-space-20: 80px;--ts-space-24: 96px;--ts-radius-sm: 3px;--ts-radius: 4px;--ts-radius-md: 6px;--ts-radius-lg: 8px;--ts-radius-pill: 999px;--ts-shadow-sm: 0 1px 2px rgba(15, 23, 42, .05);--ts-shadow: 0 4px 12px rgba(15, 23, 42, .08);--ts-shadow-lg: 0 16px 48px rgba(15, 23, 42, .12);--ts-shadow-focus: 0 0 0 3px var(--ts-accent-bg-strong);--ts-container-max: 1280px;--ts-content-max: 72ch;--ts-app-header-h: 52px;--ts-motion-fast: .12s;--ts-motion: .18s;--ts-motion-slow: .24s;--ts-ease: cubic-bezier(.2, .8, .2, 1)}.ts-mono{font-family:var(--ts-font-mono);font-variant-numeric:tabular-nums}.ts-num{font-family:var(--ts-font-mono);font-variant-numeric:tabular-nums;letter-spacing:-.01em}.ts-eyebrow{font-family:var(--ts-font-mono);font-size:var(--ts-text-2xs);font-weight:var(--ts-weight-medium);letter-spacing:var(--ts-tracking-caps);text-transform:uppercase;color:var(--ts-text-muted)}.ts-divider{height:1px;background:var(--ts-border);border:none;margin:var(--ts-space-6) 0}.ts-tag{display:inline-flex;align-items:center;gap:var(--ts-space-1);padding:2px var(--ts-space-2);border:1px solid var(--ts-border);background:var(--ts-surface-elevated);color:var(--ts-text-secondary);font-family:var(--ts-font-mono);font-size:var(--ts-text-2xs);letter-spacing:var(--ts-tracking-wide);text-transform:uppercase;border-radius:var(--ts-radius-sm);white-space:nowrap}.ts-tag--accent{border-color:var(--ts-accent-border);background:var(--ts-accent-bg);color:var(--ts-accent)}.ts-tag--success{border-color:var(--ts-success-border);background:var(--ts-success-bg);color:var(--ts-success)}.ts-tag--danger{border-color:var(--ts-danger-border);background:var(--ts-danger-bg);color:var(--ts-danger)}.ts-delta-up{color:var(--ts-success)}.ts-delta-down{color:var(--ts-danger)}.ts-delta-flat{color:var(--ts-text-muted)}*,*:before,*:after{box-sizing:border-box}html,body{margin:0;padding:0}body{min-height:100vh;background:var(--ts-bg);color:var(--ts-text);font-family:var(--ts-font-sans);font-size:var(--ts-text-base);line-height:var(--ts-leading-normal);-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;text-rendering:optimizeLegibility}#root{min-height:100vh}h1,h2,h3,h4,h5,h6{margin:0;font-weight:var(--ts-weight-semibold);line-height:var(--ts-leading-tight);letter-spacing:var(--ts-tracking-tight);color:var(--ts-text)}p{margin:0}button{font-family:inherit;font-size:inherit;cursor:pointer}input,textarea,select{font-family:inherit;font-size:inherit;color:inherit}a{color:var(--ts-info);text-decoration:none}a:hover{text-decoration:underline}::selection{background:var(--ts-accent-bg-strong);color:var(--ts-text)}*{scrollbar-width:thin;scrollbar-color:var(--ts-border-strong) transparent}*::-webkit-scrollbar{width:10px;height:10px}*::-webkit-scrollbar-track{background:transparent}*::-webkit-scrollbar-thumb{background:var(--ts-border-strong);border-radius:var(--ts-radius);border:2px solid transparent;background-clip:padding-box}*::-webkit-scrollbar-thumb:hover{background:var(--ts-text-muted);background-clip:padding-box}:root{--tour-bg: #1a1f2e;--tour-border: rgba(99, 102, 241, .35);--tour-accent: #6366f1;--tour-accent-hover: #818cf8;--tour-text: #e2e8f0;--tour-text-muted: #94a3b8;--tour-radius: 14px}.tour-tooltip{background:var(--tour-bg);border:1px solid var(--tour-border);border-radius:var(--tour-radius);box-shadow:0 25px 60px #0000008c,0 0 0 1px #0f172a0a,inset 0 1px #0f172a0f;max-width:360px;min-width:280px;padding:0;font-family:inherit;overflow:hidden}.tour-tooltip-header{display:flex;align-items:flex-start;justify-content:space-between;gap:12px;padding:18px 18px 0}.tour-tooltip-title{font-size:15px;font-weight:700;color:var(--ts-text);line-height:1.3;flex:1}.tour-close-btn{background:none;border:none;color:var(--tour-text-muted);cursor:pointer;padding:2px;border-radius:4px;transition:color .15s,background .15s;flex-shrink:0;margin-top:1px}.tour-close-btn:hover{color:var(--tour-text);background:#ffffff14}.tour-tooltip-body{padding:10px 18px 14px;font-size:13.5px;color:var(--tour-text-muted);line-height:1.6}.tour-tooltip-body p{margin:0}.tour-tooltip-body em{color:#a5b4fc;font-style:italic}.tour-tooltip-body strong{color:var(--tour-text);font-weight:600}.tour-welcome{text-align:center}.tour-welcome-icon{font-size:32px;margin-bottom:10px;filter:drop-shadow(0 0 12px rgba(99,102,241,.6))}.tour-welcome p{margin:0 0 6px;font-size:14px;color:var(--tour-text-muted);line-height:1.6}.tour-welcome-sub{font-size:12px!important;color:#64748b!important}.tour-finish{text-align:center}.tour-finish-checks{display:flex;flex-direction:column;gap:6px;background:#6366f112;border:1px solid rgba(99,102,241,.18);border-radius:10px;padding:12px 14px;margin-bottom:12px}.tour-finish-checks span{font-size:12.5px;color:#a5b4fc;text-align:left}.tour-finish-cta{font-size:13px;color:var(--tour-text-muted)}.tour-tooltip-footer{border-top:1px solid rgba(15,23,42,.06);padding:12px 18px;display:flex;align-items:center;justify-content:space-between;gap:8px}.tour-step-dots{display:flex;gap:5px;flex-shrink:0}.tour-dot{width:6px;height:6px;border-radius:50%;background:#ffffff26;transition:background .2s,transform .2s}.tour-dot.done{background:#6366f180}.tour-dot.active{background:var(--tour-accent);transform:scale(1.3)}.tour-tooltip-actions{display:flex;align-items:center;gap:6px}.tour-btn-primary{display:inline-flex;align-items:center;gap:4px;background:var(--tour-accent);color:var(--ts-text);border:none;border-radius:8px;padding:6px 14px;font-size:13px;font-weight:600;cursor:pointer;transition:background .15s,transform .1s;white-space:nowrap}.tour-btn-primary:hover{background:var(--tour-accent-hover);transform:translateY(-1px)}.tour-btn-secondary{display:inline-flex;align-items:center;gap:3px;background:var(--ts-surface-elevated);color:var(--tour-text-muted);border:1px solid rgba(255,255,255,.1);border-radius:8px;padding:6px 10px;font-size:13px;font-weight:500;cursor:pointer;transition:background .15s,color .15s;white-space:nowrap}.tour-btn-secondary:hover{background:#ffffff1f;color:var(--tour-text)}.tour-btn-skip{background:none;border:none;color:var(--ts-text-secondary);font-size:12px;cursor:pointer;padding:4px 8px;border-radius:6px;transition:color .15s;white-space:nowrap}.tour-btn-skip:hover{color:var(--tour-text-muted)}.tour-trigger-btn{display:inline-flex;align-items:center;gap:6px;background:#6366f11f;color:#a5b4fc;border:1px solid rgba(99,102,241,.25);border-radius:8px;padding:6px 12px;font-size:12.5px;font-weight:500;cursor:pointer;transition:background .15s,border-color .15s,color .15s;white-space:nowrap}.tour-trigger-btn:hover{background:#6366f138;border-color:#6366f173;color:#c7d2fe}.__floater__open .__joyride-beacon-inner{background:var(--tour-accent)!important}.__floater__open .__joyride-beacon-outer{border-color:var(--tour-accent)!important}.data-freshness-wrapper{position:relative}.data-freshness-indicator{display:inline-flex;align-items:center;gap:var(--ts-space-2);padding:4px var(--ts-space-3);background:var(--ts-surface);border:1px solid var(--ts-border);border-radius:var(--ts-radius);font-family:var(--ts-font-mono);font-size:var(--ts-text-2xs);font-weight:var(--ts-weight-medium);letter-spacing:var(--ts-tracking-wide);text-transform:uppercase;color:var(--ts-text-secondary);cursor:pointer;transition:background var(--ts-motion-fast) var(--ts-ease),border-color var(--ts-motion-fast) var(--ts-ease),color var(--ts-motion-fast) var(--ts-ease)}.data-freshness-indicator:hover{background:var(--ts-surface-hover);border-color:var(--ts-border-strong)}.data-freshness-indicator.fresh{background:var(--ts-success-bg);border-color:var(--ts-success-border);color:var(--ts-success)}.data-freshness-indicator.recent{background:var(--ts-info-bg);border-color:var(--ts-info-border);color:var(--ts-info)}.data-freshness-indicator.aging{background:var(--ts-warning-bg);border-color:var(--ts-warning-border);color:var(--ts-warning)}.data-freshness-indicator.stale{background:var(--ts-danger-bg);border-color:var(--ts-danger-border);color:var(--ts-danger)}.data-freshness-indicator.loading{background:var(--ts-surface);border-color:var(--ts-border);color:var(--ts-text-muted)}.freshness-label{display:none}@media(min-width:768px){.freshness-label{display:inline}}.spinning{animation:freshness-spin .9s linear infinite}@keyframes freshness-spin{0%{transform:rotate(0)}to{transform:rotate(360deg)}}.freshness-dropdown{position:absolute;top:100%;right:0;margin-top:var(--ts-space-1);background:var(--ts-surface-elevated);border:1px solid var(--ts-border-strong);border-radius:var(--ts-radius-md);box-shadow:var(--ts-shadow-lg);min-width:280px;z-index:100;overflow:hidden}.freshness-header{display:flex;justify-content:space-between;align-items:center;padding:var(--ts-space-3) var(--ts-space-4);border-bottom:1px solid var(--ts-border);background:var(--ts-surface)}.freshness-header h4{margin:0;font-family:var(--ts-font-mono);font-size:var(--ts-text-2xs);text-transform:uppercase;letter-spacing:var(--ts-tracking-caps);font-weight:var(--ts-weight-semibold);color:var(--ts-text-muted)}.refresh-all-btn{display:inline-flex;align-items:center;gap:var(--ts-space-1);padding:4px var(--ts-space-2);background:var(--ts-accent-bg);border:1px solid var(--ts-accent-border);color:var(--ts-accent);cursor:pointer;border-radius:var(--ts-radius-sm);font-family:var(--ts-font-sans);font-size:var(--ts-text-xs);font-weight:var(--ts-weight-medium);transition:background var(--ts-motion-fast) var(--ts-ease)}.refresh-all-btn:hover:not(:disabled){background:var(--ts-accent-bg-strong)}.refresh-all-btn:disabled{opacity:.5;cursor:not-allowed}.freshness-trigger-msg{padding:var(--ts-space-2) var(--ts-space-3);margin:var(--ts-space-2) var(--ts-space-3) 0;background:var(--ts-accent-bg);color:var(--ts-accent);border:1px solid var(--ts-accent-border);border-radius:var(--ts-radius);font-size:var(--ts-text-xs);line-height:var(--ts-leading-snug)}.freshness-list{padding:var(--ts-space-2) 0}.freshness-item{display:flex;justify-content:space-between;align-items:center;padding:6px var(--ts-space-4);font-size:var(--ts-text-sm)}.freshness-item:hover{background:var(--ts-surface-hover)}.freshness-name{color:var(--ts-text-secondary)}.freshness-time{font-family:var(--ts-font-mono);font-size:var(--ts-text-xs);font-weight:var(--ts-weight-medium);color:var(--ts-text-muted)}.freshness-item.fresh .freshness-time{color:var(--ts-success)}.freshness-item.recent .freshness-time{color:var(--ts-info)}.freshness-item.aging .freshness-time{color:var(--ts-warning)}.freshness-item.stale .freshness-time{color:var(--ts-danger)}.legal-page{min-height:100vh;background:linear-gradient(135deg,#0f172a,#1e293b);color:var(--ts-text)}.legal-header{display:flex;justify-content:space-between;align-items:center;padding:1rem 2rem;background:var(--ts-surface-elevated);-webkit-backdrop-filter:blur(10px);backdrop-filter:blur(10px);border-bottom:1px solid var(--ts-border);position:sticky;top:0;z-index:100}.legal-logo{display:flex;align-items:center;gap:.75rem;font-size:1.25rem;font-weight:600;color:var(--ts-text)}.legal-logo svg{color:var(--ts-accent)}.legal-back-btn{display:flex;align-items:center;gap:.5rem;padding:.5rem 1rem;background:#94a3b81a;border:1px solid var(--ts-border);border-radius:8px;color:var(--ts-text-muted);font-size:.875rem;cursor:pointer;transition:all .2s}.legal-back-btn:hover{background:#94a3b833;color:var(--ts-text)}.legal-content{max-width:800px;margin:0 auto;padding:3rem 2rem}.legal-content h1{font-size:2.5rem;font-weight:700;color:var(--ts-text);margin-bottom:.5rem}.legal-date{color:var(--ts-text-muted);margin-bottom:3rem;font-size:.875rem}.legal-content section{margin-bottom:2.5rem}.legal-content h2{font-size:1.5rem;font-weight:600;color:var(--ts-text);margin-bottom:1rem;padding-bottom:.5rem;border-bottom:1px solid var(--ts-border)}.legal-content h3{font-size:1.125rem;font-weight:600;color:var(--ts-text);margin-top:1.5rem;margin-bottom:.75rem}.legal-content p{color:var(--ts-text-secondary);line-height:1.7;margin-bottom:1rem}.legal-content ul{margin:1rem 0;padding-left:1.5rem}.legal-content li{color:var(--ts-text-secondary);line-height:1.7;margin-bottom:.5rem}.legal-content li strong,.legal-content strong{color:var(--ts-text)}.legal-footer{text-align:center;padding:2rem;border-top:1px solid var(--ts-border);color:#64748b;font-size:.875rem}@media(max-width:768px){.legal-header{padding:1rem}.legal-content{padding:2rem 1rem}.legal-content h1{font-size:1.75rem}.legal-content h2{font-size:1.25rem}}.cal-page .legal-content{max-width:960px}.cal-state{display:flex;align-items:center;gap:.75rem;padding:1.5rem;background:var(--ts-surface-elevated);border:1px dashed var(--ts-border);border-radius:8px;color:var(--ts-text-muted);flex-direction:column;align-items:flex-start}.cal-state code{background:var(--ts-surface-elevated);color:var(--ts-accent);padding:.1rem .4rem;border-radius:4px;font-size:.85em}.cal-state--error{color:var(--ts-danger);border-color:#f871714d;background:var(--ts-danger-bg)}.cal-state-sub{color:#64748b;font-size:.85rem;margin-top:.25rem}.cal-spin{animation:cal-spin 1s linear infinite}@keyframes cal-spin{0%{transform:rotate(0)}to{transform:rotate(360deg)}}.cal-metrics-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(180px,1fr));gap:1rem;margin-top:.5rem}.cal-metric{background:var(--ts-surface-elevated);border:1px solid var(--ts-border);border-radius:8px;padding:1rem 1.1rem}.cal-metric-val{font-size:1.6rem;font-weight:600;color:var(--ts-text);font-variant-numeric:tabular-nums}.cal-metric-label{font-size:.75rem;color:var(--ts-text-muted);text-transform:uppercase;letter-spacing:.05em;margin-top:.25rem}.cal-metric-hint{color:#64748b;font-size:.75rem;margin-top:.5rem;line-height:1.4}.cal-diagram-wrap{display:grid;grid-template-columns:minmax(280px,1fr) minmax(280px,1fr);gap:1.5rem;align-items:start;margin-top:1rem}@media(max-width:720px){.cal-diagram-wrap{grid-template-columns:1fr}}.cal-svg{width:100%;max-width:420px;height:auto;display:block}.cal-bin-table,.cal-phase-table{width:100%;border-collapse:collapse;font-size:.85rem;background:var(--ts-surface-elevated);border:1px solid var(--ts-border);border-radius:8px;overflow:hidden}.cal-bin-table thead th,.cal-phase-table thead th{background:var(--ts-surface-elevated);color:var(--ts-text-muted);font-weight:500;text-transform:uppercase;font-size:.7rem;letter-spacing:.05em;padding:.5rem .7rem;text-align:left;border-bottom:1px solid var(--ts-border)}.cal-bin-table tbody td,.cal-phase-table tbody td{padding:.5rem .7rem;border-bottom:1px solid var(--ts-border);color:var(--ts-text-secondary)}.cal-bin-table tbody tr:last-child td,.cal-phase-table tbody tr:last-child td{border-bottom:none}.cal-num{text-align:right;font-variant-numeric:tabular-nums}.cal-ok{color:var(--ts-success)}.cal-warn{color:var(--ts-warning)}.cal-bad{color:var(--ts-danger)}.cal-notable-grid{display:grid;grid-template-columns:1fr 1fr;gap:1.5rem;margin-top:.75rem}@media(max-width:720px){.cal-notable-grid{grid-template-columns:1fr}}.cal-notable-grid h3{font-size:1rem;color:var(--ts-text);margin:0 0 .5rem;padding-bottom:.4rem;border-bottom:1px solid var(--ts-border)}.cal-trial-list{list-style:none;padding:0;margin:0;display:flex;flex-direction:column;gap:.6rem}.cal-trial-list li{display:flex;flex-direction:column;gap:.15rem;font-size:.85rem;padding:.5rem .7rem;background:var(--ts-surface-elevated);border:1px solid var(--ts-border);border-radius:6px}.cal-trial-list a{color:var(--ts-accent);font-weight:600;text-decoration:none}.cal-trial-list a:hover{text-decoration:underline}.cal-trial-meta{font-size:.75rem;color:var(--ts-text-muted)}.cal-trial-meta--wrong{color:var(--ts-danger)}.cal-trial-title{color:var(--ts-text-secondary);font-size:.8rem;line-height:1.4}.cal-muted{color:#64748b;font-size:.85rem}.lp-page{background:var(--ts-bg);color:var(--ts-text);font-family:var(--ts-font-sans);min-height:100vh}.lp-header{position:sticky;top:0;z-index:50;background:#ffffffd9;backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border-bottom:1px solid var(--ts-border)}.lp-header-inner{max-width:var(--ts-container-max);margin:0 auto;padding:0 var(--ts-space-6);height:var(--ts-app-header-h);display:flex;align-items:center;gap:var(--ts-space-8)}.lp-brand{display:inline-flex;align-items:center;gap:var(--ts-space-2);color:var(--ts-text);text-decoration:none;font-weight:var(--ts-weight-semibold)}.lp-brand-dot{display:inline-block;width:10px;height:10px;background:var(--ts-accent);border-radius:2px;box-shadow:0 0 12px #d9770673}.lp-brand-name{font-family:var(--ts-font-sans);font-size:var(--ts-text-md);letter-spacing:var(--ts-tracking-tight)}.lp-nav{display:flex;align-items:center;gap:var(--ts-space-6);margin-left:auto}.lp-nav a{font-family:var(--ts-font-mono);font-size:var(--ts-text-xs);color:var(--ts-text-secondary);text-decoration:none;letter-spacing:var(--ts-tracking-wide);transition:color var(--ts-motion) var(--ts-ease)}.lp-nav a:hover{color:var(--ts-text)}.lp-header-cta{display:flex;align-items:center;gap:var(--ts-space-2)}.lp-btn{display:inline-flex;align-items:center;justify-content:center;gap:var(--ts-space-2);padding:8px 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var(--ts-border)}.lp-hero:before{content:"";position:absolute;inset:0;background-image:radial-gradient(circle,rgba(15,23,42,.04) 1px,transparent 1px);background-size:24px 24px;pointer-events:none}.lp-hero-grid{position:relative;max-width:var(--ts-container-max);margin:0 auto;padding:var(--ts-space-16) var(--ts-space-6) var(--ts-space-20);display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.1fr);gap:var(--ts-space-10);align-items:center}@media(max-width:960px){.lp-hero-grid{grid-template-columns:1fr;padding-top:var(--ts-space-10);padding-bottom:var(--ts-space-12)}}.lp-hero-text h1{font-size:clamp(36px,5vw,var(--ts-text-5xl));line-height:1.05;letter-spacing:-.02em;font-weight:var(--ts-weight-bold);margin:var(--ts-space-4) 0 var(--ts-space-5)}.lp-hero-text h1 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.date-label{font-size:.65rem;color:var(--ts-text-muted);text-transform:uppercase;display:block}.launch-date .date-value{font-size:.8rem;font-weight:600;color:var(--text-primary)}.launch-date.fda .date-value{color:var(--ts-accent)}.launch-date.launch .date-value{color:#22c55e}.launch-confidence{font-size:.7rem;font-weight:600;padding:.25rem .5rem;border-radius:6px;text-transform:uppercase}.launch-confidence.high{background:#dcfce7;color:#16a34a}.launch-confidence.medium{background:#fef3c7;color:#d97706}.launch-confidence.low{background:#fee2e2;color:#dc2626}.indication-bars{display:flex;flex-direction:column;gap:.6rem}.indication-row{display:flex;align-items:center;gap:.75rem}.indication-name{width:140px;font-size:.8rem;color:var(--ts-text);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.indication-bar-container{flex:1;height:20px;background:var(--ts-surface-elevated);border-radius:4px;overflow:hidden}.indication-bar{height:100%;background:linear-gradient(90deg,var(--accent) 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button:hover{background:#b97a18}@media(max-width:1200px){.kpi-grid{grid-template-columns:repeat(2,1fr)}.dashboard-quad{grid-template-columns:1fr}}@media(max-width:768px){.kpi-grid{grid-template-columns:1fr}.kpi-card{padding:1rem}.kpi-value{font-size:1.5rem}.quad-content{max-height:none}.milestone-item{flex-direction:column;align-items:flex-start}.milestone-enrollment{margin-top:.5rem}.launch-item{flex-direction:column;align-items:flex-start}.launch-dates,.launch-confidence{margin-top:.5rem}.watchlist-cards{grid-template-columns:1fr}}.auth-loading{display:flex;flex-direction:column;align-items:center;justify-content:center;min-height:100vh;color:var(--ts-text-muted);background:var(--ts-bg)}.auth-loading svg{color:var(--ts-accent);margin-bottom:var(--ts-space-3)}.spinner{width:24px;height:24px;border:2px solid var(--ts-border);border-top-color:var(--ts-accent);border-radius:50%;animation:spin .9s linear 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var(--ts-border);border-radius:20px;background:var(--ts-surface);color:var(--ts-text-secondary);font-size:.85rem;cursor:pointer;transition:all .15s;font-family:inherit}.indication-chip:hover{border-color:var(--primary);color:var(--primary);background:#eef2ff}.indication-chip.selected{border-color:var(--primary);background:var(--primary);color:var(--ts-text)}.selected-count,.selected-indications-summary{text-align:center;color:var(--primary);font-weight:600;font-size:.9rem;padding:8px 0}.onboarding-notifications{margin-top:24px}.notification-option{margin-bottom:20px}.notification-option>label{display:flex;align-items:center;gap:12px;font-weight:500;color:var(--ts-text);cursor:pointer}.notification-option select{width:100%;padding:10px 12px;border:2px solid var(--ts-border);border-radius:8px;font-size:1rem;margin-top:8px;cursor:pointer}.notification-types{margin-top:24px;padding:16px;background:var(--ts-surface);border-radius:12px}.notification-types h4{font-size:.875rem;color:#64748b;margin-bottom:12px}.notification-types label{display:flex;align-items:center;gap:10px;padding:8px 0;cursor:pointer;color:var(--ts-text-secondary)}.onboarding-complete{text-align:center;padding:24px 0}.complete-icon{color:#22c55e;margin-bottom:16px}.onboarding-complete p{color:#64748b}.onboarding-actions{display:flex;justify-content:space-between;align-items:center;padding:24px;border-top:1px solid var(--ts-border)}.action-right{display:flex;gap:12px;align-items:center}.onboarding-btn{display:inline-flex;align-items:center;gap:8px;padding:12px 24px;border-radius:8px;font-size:1rem;font-weight:500;cursor:pointer;transition:all .2s}.onboarding-btn.primary{background:linear-gradient(135deg,var(--primary),var(--accent));color:#fff;border:none}.onboarding-btn.primary:hover{transform:translateY(-1px);box-shadow:0 4px 12px 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h2{display:flex;align-items:center;gap:12px;font-size:1.25rem;color:var(--ts-text)}.settings-header .close-btn{background:none;border:none;cursor:pointer;padding:8px;border-radius:8px;color:#64748b;transition:all .2s}.settings-header .close-btn:hover{background:var(--ts-surface-elevated);color:var(--ts-text)}.settings-tabs{display:flex;gap:4px;padding:12px 24px;background:var(--ts-surface);border-bottom:1px solid var(--ts-border)}.settings-tab{display:flex;align-items:center;gap:8px;padding:10px 16px;border:none;background:none;cursor:pointer;border-radius:8px;font-size:.875rem;font-weight:500;color:#64748b;transition:all .2s}.settings-tab:hover{background:var(--ts-surface-elevated);color:var(--ts-text)}.settings-tab.active{background:var(--ts-surface);color:var(--primary);box-shadow:var(--ts-shadow-sm)}.settings-content{flex:1;overflow-y:auto;padding:24px}.settings-section{max-width:100%}.settings-loading{text-align:center;padding:40px;color:#64748b}.settings-error{display:flex;align-items:center;gap:8px;padding:12px 16px;background:#fef2f2;color:#dc2626;border-radius:8px;margin-bottom:20px}.settings-group{margin-bottom:32px}.settings-group h3{display:flex;align-items:center;gap:10px;font-size:1rem;color:var(--ts-text);margin-bottom:16px;padding-bottom:8px;border-bottom:1px solid var(--ts-border)}.group-description{color:#64748b;font-size:.875rem;margin-bottom:16px}.setting-row{display:flex;justify-content:space-between;align-items:flex-start;padding:16px 0;border-bottom:1px solid #f1f5f9}.setting-row:last-child{border-bottom:none}.setting-info{flex:1}.setting-info label{display:block;font-weight:500;color:var(--ts-text);margin-bottom:4px}.setting-description{font-size:.875rem;color:#64748b}.setting-row select{padding:8px 12px;border:1px solid var(--ts-border);border-radius:6px;font-size:.875rem;cursor:pointer;min-width:180px}.toggle{position:relative;display:inline-block;width:48px;height:26px;flex-shrink:0}.toggle input{opacity:0;width:0;height:0}.toggle-slider{position:absolute;cursor:pointer;inset:0;background-color:var(--ts-text-secondary);transition:.3s;border-radius:26px}.toggle-slider:before{position:absolute;content:"";height:20px;width:20px;left:3px;bottom:3px;background-color:var(--ts-surface);transition:.3s;border-radius:50%;box-shadow:var(--ts-shadow-sm)}.toggle input:checked+.toggle-slider{background-color:var(--primary)}.toggle input:checked+.toggle-slider:before{transform:translate(22px)}.settings-actions{margin-top:24px;padding-top:24px;border-top:1px solid var(--ts-border);display:flex;justify-content:flex-end}.save-btn{display:inline-flex;align-items:center;gap:8px;padding:12px 24px;background:linear-gradient(135deg,var(--primary),var(--accent));color:#fff;border:none;border-radius:8px;font-size:.875rem;font-weight:500;cursor:pointer;transition:all .2s}.save-btn:hover:not(:disabled){transform:translateY(-1px);box-shadow:0 4px 12px #6366f166}.save-btn:disabled{opacity:.7;cursor:not-allowed}.save-btn .spinning{animation:spin 1s linear infinite}.scheduler-status{margin-bottom:20px}.status-badge{display:inline-flex;align-items:center;gap:6px;padding:6px 12px;border-radius:20px;font-size:.75rem;font-weight:600;text-transform:uppercase}.status-badge.running{background:#dcfce7;color:#166534}.status-badge.stopped{background:#fef2f2;color:#dc2626}.scheduled-jobs{margin-bottom:24px}.scheduled-jobs h4,.recent-logs h4{font-size:.875rem;color:#64748b;margin-bottom:12px}.jobs-list{background:var(--ts-surface);border-radius:8px;overflow:hidden}.job-item{padding:12px 16px;border-bottom:1px solid var(--ts-border)}.job-item:last-child{border-bottom:none}.job-name{display:block;font-weight:500;color:var(--ts-text);margin-bottom:4px}.job-next{font-size:.75rem;color:#64748b}.logs-list{background:var(--ts-surface);border-radius:8px;overflow:hidden}.log-item{display:flex;align-items:center;gap:12px;padding:10px 16px;border-bottom:1px solid var(--ts-border)}.log-item:last-child{border-bottom:none}.log-info{flex:1}.log-type{display:block;font-weight:500;color:var(--ts-text);font-size:.875rem}.log-time{font-size:.75rem;color:#64748b}.log-stats{display:flex;gap:12px;font-size:.75rem;color:#64748b}.log-status{font-size:.75rem;font-weight:600;text-transform:uppercase;padding:2px 8px;border-radius:4px}.log-status.completed{background:#dcfce7;color:#166534}.log-status.failed{background:#fef2f2;color:#dc2626}.log-status.started{background:#fef3c7;color:#92400e}.refresh-buttons{display:flex;gap:12px;flex-wrap:wrap}.refresh-btn{display:inline-flex;align-items:center;gap:8px;padding:10px 16px;background:var(--ts-surface-elevated);border:1px solid var(--ts-border);border-radius:8px;font-size:.875rem;font-weight:500;color:var(--ts-text-secondary);cursor:pointer;transition:all .2s}.refresh-btn:hover{background:var(--ts-surface-elevated);border-color:var(--ts-border-strong)}.toggle-row{align-items:center}.export-cards{display:grid;grid-template-columns:repeat(auto-fit,minmax(250px,1fr));gap:1rem;margin-top:1rem}.export-card{background:var(--ts-surface);border:1px solid var(--ts-border);border-radius:12px;padding:1.25rem}.export-card-header{display:flex;justify-content:space-between;align-items:center;margin-bottom:.5rem}.export-card-header h4{margin:0;font-size:1rem;font-weight:600;color:var(--ts-text)}.export-format{background:#e0e7ff;color:#4f46e5;padding:.25rem .5rem;border-radius:4px;font-size:.75rem;font-weight:600}.export-card p{color:#64748b;font-size:.875rem;margin:.5rem 0 1rem;line-height:1.5}.export-btn{display:inline-flex;align-items:center;gap:8px;padding:10px 16px;background:linear-gradient(135deg,var(--primary),var(--accent));border:none;border-radius:8px;font-size:.875rem;font-weight:500;color:#fff;cursor:pointer;transition:all .2s;width:100%;justify-content:center}.export-btn:hover{transform:translateY(-1px);box-shadow:0 4px 12px #6366f14d}.export-btn:active{transform:translateY(0)}.billing-current-plan{margin-bottom:24px}.billing-plan-info{margin-bottom:16px}.billing-plan-name{display:flex;align-items:center;gap:8px;font-size:1.15rem;font-weight:700;color:var(--text-primary, #1e293b);margin-bottom:6px}.billing-plan-status{font-size:.85rem;color:var(--text-muted, #64748b)}.billing-status.active{color:#22c55e;font-weight:600}.billing-status.past_due{color:var(--ts-accent);font-weight:600}.billing-status.canceled{color:#ef4444;font-weight:600}.billing-upgrade-card{background:linear-gradient(135deg,#6366f114,#f5a52414);border:1px solid rgba(99,102,241,.2);border-radius:12px;padding:24px;margin-bottom:20px}.billing-upgrade-card h4{margin:0 0 8px;color:var(--text-primary, #1e293b);font-size:1.05rem}.billing-upgrade-card p{margin:0 0 12px;color:var(--text-secondary, #475569);font-size:.9rem;line-height:1.5}.billing-price{font-size:2rem;font-weight:800;color:var(--text-primary, #1e293b);margin-bottom:16px}.billing-price span{font-size:.9rem;font-weight:400;color:var(--text-muted, #64748b)}.billing-upgrade-btn{display:inline-flex;align-items:center;gap:8px;padding:10px 28px;background:linear-gradient(135deg,var(--primary),var(--accent));color:#fff;border:none;border-radius:8px;font-size:.95rem;font-weight:600;cursor:pointer;transition:all .2s}.billing-upgrade-btn:hover{transform:translateY(-1px);box-shadow:0 4px 16px #6366f166}.billing-manage-btn{display:inline-flex;align-items:center;gap:8px;padding:8px 20px;background:transparent;color:var(--primary, var(--primary));border:1px solid var(--primary, var(--primary));border-radius:8px;font-size:.9rem;font-weight:500;cursor:pointer;transition:all .2s}.billing-manage-btn:hover{background:#6366f10d}.billing-features-comparison{margin-top:24px}.billing-features-comparison h4{margin:0 0 12px;font-size:.95rem;color:var(--text-primary, #1e293b)}.billing-table{width:100%;border-collapse:collapse;font-size:.85rem}.billing-table th,.billing-table td{padding:8px 12px;text-align:left;border-bottom:1px solid var(--border-light, #e2e8f0)}.billing-table th{font-weight:600;color:var(--text-primary, #1e293b);font-size:.8rem;text-transform:uppercase;letter-spacing:.05em}.billing-table td{color:var(--text-secondary, #475569)}.billing-table td:nth-child(2),.billing-table td:nth-child(3),.billing-table th:nth-child(2),.billing-table th:nth-child(3){text-align:center}.billing-table svg{color:#22c55e}.settings-tab.danger{color:#ef4444}.settings-tab.danger:hover,.settings-tab.danger.active{background:#fef2f2;color:#dc2626}.account-section h3{font-size:1.125rem;color:var(--ts-text);margin-bottom:1.5rem}.account-card{background:var(--ts-surface);border:1px solid var(--ts-border);border-radius:12px;padding:1.5rem;margin-bottom:1.5rem}.account-card.danger{background:#fef2f2;border-color:#fecaca}.account-card-header{display:flex;gap:1rem;margin-bottom:1rem}.account-card-header svg{flex-shrink:0;color:#64748b}.account-card.danger .account-card-header svg{color:#ef4444}.account-card-header h4{font-size:1rem;color:var(--ts-text);margin-bottom:.25rem}.account-card-header p{font-size:.875rem;color:#64748b;margin:0}.btn-export-data{display:inline-flex;align-items:center;gap:.5rem;padding:.625rem 1rem;background:var(--primary);color:#fff;border:none;border-radius:8px;font-size:.875rem;font-weight:500;cursor:pointer;transition:all .2s}.btn-export-data:hover{background:#4f46e5}.btn-delete-account{display:inline-flex;align-items:center;gap:.5rem;padding:.625rem 1rem;background:#ef4444;color:#fff;border:none;border-radius:8px;font-size:.875rem;font-weight:500;cursor:pointer;transition:all .2s}.btn-delete-account:hover{background:#dc2626}.delete-confirm-form{margin-top:1rem}.delete-warning{display:flex;gap:1rem;padding:1rem;background:#fef2f2;border:1px solid #fecaca;border-radius:8px;margin-bottom:1.5rem}.delete-warning svg{flex-shrink:0;color:#ef4444}.delete-warning strong{color:#dc2626}.delete-warning ul{margin:.5rem 0 0 1rem;padding:0;font-size:.875rem;color:#7f1d1d}.delete-warning li{margin-bottom:.25rem}.delete-form-group{margin-bottom:1rem}.delete-form-group label{display:block;font-size:.875rem;font-weight:500;color:var(--ts-text);margin-bottom:.5rem}.delete-form-group input{width:100%;padding:.625rem;border:1px solid var(--ts-border-strong);border-radius:8px;font-size:.875rem}.delete-form-group input:focus{outline:none;border-color:#ef4444;box-shadow:0 0 0 3px #ef44441a}.delete-actions{display:flex;gap:1rem;margin-top:1.5rem}.delete-actions .btn-cancel{padding:.625rem 1rem;background:var(--ts-surface);border:1px solid var(--ts-border);border-radius:8px;font-size:.875rem;cursor:pointer;transition:all .2s}.delete-actions .btn-cancel:hover{background:var(--ts-surface-elevated)}.delete-actions .btn-confirm-delete{flex:1;padding:.625rem 1rem;background:#ef4444;color:#fff;border:none;border-radius:8px;font-size:.875rem;font-weight:500;cursor:pointer;transition:all .2s}.delete-actions .btn-confirm-delete:hover:not(:disabled){background:#dc2626}.delete-actions .btn-confirm-delete:disabled{opacity:.5;cursor:not-allowed}.upgrade-prompt{display:flex;flex-direction:column;align-items:center;justify-content:center;text-align:center;padding:48px 32px;min-height:300px}.upgrade-prompt-icon{display:flex;align-items:center;justify-content:center;width:64px;height:64px;background:linear-gradient(135deg,#6366f11a,#f5a5241a);border-radius:16px;margin-bottom:20px;color:var(--primary)}.upgrade-prompt h3{margin:0 0 8px;font-size:1.2rem;color:var(--text-primary, #1e293b)}.upgrade-prompt p{margin:0 0 24px;color:var(--text-muted, #64748b);font-size:.95rem;max-width:400px;line-height:1.5}.upgrade-prompt-btn{display:inline-flex;align-items:center;gap:8px;padding:12px 32px;background:linear-gradient(135deg,var(--primary),var(--accent));color:#fff;border:none;border-radius:10px;font-size:1rem;font-weight:600;cursor:pointer;transition:all .2s}.upgrade-prompt-btn:hover{transform:translateY(-2px);box-shadow:0 6px 20px #6366f166}:root{--primary: var(--primary);--primary-hover: #4f46e5;--primary-light: #e0e7ff;--secondary: var(--accent);--secondary-hover: #b97a18;--success: #10b981;--success-light: #d1fae5;--warning: #f59e0b;--warning-light: #fef3c7;--danger: #ef4444;--danger-light: #fee2e2;--info: #3b82f6;--info-light: #dbeafe;--bg-primary: #ffffff;--bg-secondary: #f8fafc;--bg-tertiary: #f1f5f9;--bg-hover: #e2e8f0;--text-primary: #1e293b;--text-secondary: #64748b;--text-tertiary: #94a3b8;--border-color: var(--ts-border);--border-focus: var(--primary);--shadow-sm: 0 1px 2px rgba(0, 0, 0, .05);--shadow-md: 0 4px 6px -1px rgba(0, 0, 0, .1), 0 2px 4px -2px rgba(0, 0, 0, .1);--shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, .1), 0 4px 6px -4px rgba(0, 0, 0, .1);--shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, .1), 0 8px 10px -6px rgba(0, 0, 0, .1);--transition-fast: .15s ease;--transition-base: .2s ease;--transition-slow: .3s ease;--radius-sm: 4px;--radius-md: 8px;--radius-lg: 12px;--radius-xl: 16px;--radius-full: 9999px}[data-theme=dark]{--primary: #818cf8;--primary-hover: var(--primary);--primary-light: #312e81;--secondary: #fab43d;--secondary-hover: var(--accent);--success: #34d399;--success-light: #064e3b;--warning: #fbbf24;--warning-light: #78350f;--danger: #f87171;--danger-light: #7f1d1d;--info: #60a5fa;--info-light: #1e3a5f;--bg-primary: #0f172a;--bg-secondary: #1e293b;--bg-tertiary: #334155;--bg-hover: #475569;--text-primary: #f1f5f9;--text-secondary: #94a3b8;--text-tertiary: #64748b;--border-color: var(--ts-text);--border-focus: #818cf8;--shadow-sm: 0 1px 2px rgba(0, 0, 0, .3);--shadow-md: 0 4px 6px -1px rgba(0, 0, 0, .4), 0 2px 4px -2px rgba(0, 0, 0, .3);--shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, .4), 0 4px 6px -4px rgba(0, 0, 0, .3);--shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, .5), 0 8px 10px -6px rgba(0, 0, 0, .4)}[data-theme=dark] .time-filter select,[data-theme=dark] .time-filter select option,[data-theme=dark] .changes-summary .summary-stat .stat-value,[data-theme=dark] .changes-list h4,[data-theme=dark] .change-description,[data-theme=dark] .change-trial-info h5,[data-theme=dark] .value-content,[data-theme=dark] .drug-name,[data-theme=dark] .pres-asset,[data-theme=dark] .conf-abbr,[data-theme=dark] .step-header h2,[data-theme=dark] .feature-text h4,[data-theme=dark] .asset-result-item .asset-name,[data-theme=dark] .notification-option>label,[data-theme=dark] .settings-header h2,[data-theme=dark] .settings-group h3,[data-theme=dark] .setting-info label,[data-theme=dark] .job-name,[data-theme=dark] .log-type,[data-theme=dark] .export-card-header h4,[data-theme=dark] .account-section h3,[data-theme=dark] .account-card-header h4{color:var(--text-primary)}[data-theme=dark] .buzz-filter select,[data-theme=dark] .onboarding-asset-search input,[data-theme=dark] .indication-filter input{color:var(--text-primary);background-color:var(--bg-secondary);border-color:var(--border-color)}[data-theme=dark] .settings-tab:hover,[data-theme=dark] .settings-header .close-btn:hover,[data-theme=dark] .onboarding-close:hover,[data-theme=dark] .onboarding-btn.text:hover{color:var(--text-primary)}[data-theme=dark] body{background:var(--bg-primary);color:var(--text-primary)}[data-theme=dark] .app{background:var(--bg-primary)}[data-theme=dark] .header{background:linear-gradient(135deg,#0f172a,#1e293b)}[data-theme=dark] .stat-card,[data-theme=dark] .trial-card,[data-theme=dark] .news-card,[data-theme=dark] .alert-card,[data-theme=dark] .watchlist-group,[data-theme=dark] .settings-modal,[data-theme=dark] .modal-overlay>div,[data-theme=dark] .export-card{background:var(--bg-secondary);border-color:var(--border-color)}[data-theme=dark] .search-input,[data-theme=dark] .filter-select,[data-theme=dark] input,[data-theme=dark] select,[data-theme=dark] textarea{background:var(--bg-tertiary);border-color:var(--border-color);color:var(--text-primary)}[data-theme=dark] .search-input:focus,[data-theme=dark] input:focus,[data-theme=dark] select:focus{border-color:var(--border-focus);box-shadow:0 0 0 3px #6366f133}[data-theme=dark] .main{background:var(--bg-primary)}[data-theme=dark] .kpi-card,[data-theme=dark] .quad-card,[data-theme=dark] .asset-card,[data-theme=dark] .milestone-item,[data-theme=dark] .launch-item,[data-theme=dark] .indication-item,[data-theme=dark] .landscape-card,[data-theme=dark] .sponsor-card,[data-theme=dark] .modal,[data-theme=dark] .trial-detail,[data-theme=dark] .filter-section{background:var(--bg-secondary);border-color:var(--border-color)}[data-theme=dark] h1,[data-theme=dark] h2,[data-theme=dark] h3,[data-theme=dark] h4,[data-theme=dark] .trial-title,[data-theme=dark] .news-title a,[data-theme=dark] .asset-info h3,[data-theme=dark] .kpi-value,[data-theme=dark] .stat-value,[data-theme=dark] .quad-header h3,[data-theme=dark] .milestone-title,[data-theme=dark] .launch-asset,[data-theme=dark] .alert-title{color:var(--text-primary)}[data-theme=dark] p,[data-theme=dark] span,[data-theme=dark] .trial-meta,[data-theme=dark] .news-summary p,[data-theme=dark] .kpi-label,[data-theme=dark] .kpi-sub,[data-theme=dark] .stat-label,[data-theme=dark] .milestone-sponsor,[data-theme=dark] .milestone-meta,[data-theme=dark] .alert-message,[data-theme=dark] .alert-meta,[data-theme=dark] .news-date,[data-theme=dark] .asset-notes,[data-theme=dark] label{color:var(--text-secondary)}[data-theme=dark] .trial-card,[data-theme=dark] .news-card,[data-theme=dark] .alert-card,[data-theme=dark] .asset-card,[data-theme=dark] .kpi-card,[data-theme=dark] .quad-card{border:1px solid var(--border-color)}[data-theme=dark] .milestone-item,[data-theme=dark] .launch-item,[data-theme=dark] .indication-item{border-bottom-color:var(--border-color)}[data-theme=dark] .filter-section,[data-theme=dark] .search-section,[data-theme=dark] .stats-grid .stat-card{background:var(--bg-secondary)}[data-theme=dark] .search-mode-toggle{background:var(--bg-tertiary)}[data-theme=dark] .mode-toggle-btn{color:var(--text-secondary)}[data-theme=dark] .mode-toggle-btn:hover{color:var(--text-primary)}[data-theme=dark] .mode-toggle-btn.active{background:var(--bg-primary);color:var(--primary)}[data-theme=dark] .ai-search-input-wrapper{background:linear-gradient(135deg,#f5a5241a,#6366f11a);border-color:var(--ts-accent-border)}[data-theme=dark] .ai-search-input-wrapper:focus-within{border-color:var(--accent);box-shadow:0 0 0 3px #f5a52433}[data-theme=dark] .ai-search-input{color:var(--text-primary)}[data-theme=dark] .ai-search-input::placeholder{color:var(--text-tertiary)}[data-theme=dark] .ai-interpretation{background:#22c55e1a;border-left-color:#22c55e;color:var(--ts-success)}[data-theme=dark] .ai-interpretation svg{color:#22c55e}[data-theme=dark] .examples-label{color:var(--text-tertiary)}[data-theme=dark] .example-query{background:var(--bg-tertiary);border-color:var(--border-color);color:var(--text-secondary)}[data-theme=dark] .example-query:hover{background:var(--bg-hover);border-color:var(--accent);color:var(--primary)}[data-theme=dark] .quad-content,[data-theme=dark] 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100%)}[data-theme=dark] .alert-card.severity-high{border-left-color:var(--ts-accent);background:linear-gradient(90deg,rgba(120,53,15,.3) 0%,var(--bg-secondary) 100%)}[data-theme=dark] .alert-card.severity-medium{border-left-color:#3b82f6;background:linear-gradient(90deg,rgba(30,58,95,.3) 0%,var(--bg-secondary) 100%)}[data-theme=dark] .alert-card.severity-low{border-left-color:#10b981;background:linear-gradient(90deg,rgba(6,78,59,.3) 0%,var(--bg-secondary) 100%)}[data-theme=dark] .news-card{background:var(--bg-secondary)}[data-theme=dark] .news-card-header{background:var(--bg-tertiary);border-bottom-color:var(--border-color)}[data-theme=dark] .news-asset-tag{background:var(--primary-light);color:var(--primary)}[data-theme=dark] .news-summary{background:var(--bg-tertiary);border-color:var(--border-color)}[data-theme=dark] .read-more{color:var(--primary)}[data-theme=dark] .watchlist-view,[data-theme=dark] .watchlist-header{background:transparent}[data-theme=dark] .watchlist-title h2{color:var(--text-primary)}[data-theme=dark] .add-asset-btn{background:var(--primary);color:#fff;border:none}[data-theme=dark] .asset-card{background:var(--bg-secondary);border-color:var(--border-color)}[data-theme=dark] .asset-header{background:var(--bg-secondary)}[data-theme=dark] .asset-header:hover{background:var(--bg-tertiary)}[data-theme=dark] .asset-info h3{color:var(--text-primary)}[data-theme=dark] .asset-notes{color:var(--text-secondary)}[data-theme=dark] .asset-stats .stat-num{color:var(--text-primary)}[data-theme=dark] .asset-stats .stat-txt{color:var(--text-secondary)}[data-theme=dark] .remove-btn{color:var(--text-tertiary)}[data-theme=dark] .remove-btn:hover{background:#ef444433;color:var(--ts-danger)}[data-theme=dark] .compare-hint{background:var(--bg-tertiary);color:var(--text-secondary)}[data-theme=dark] .clear-selection-btn{border-color:var(--border-color);color:var(--text-secondary)}[data-theme=dark] .clear-selection-btn:hover{background:var(--bg-tertiary);color:var(--text-primary)}[data-theme=dark] .asset-card.selected-for-compare{border-color:var(--accent);box-shadow:0 0 0 2px #f5a5244d}[data-theme=dark] .asset-card.selected-for-removal{border-color:#ef4444;box-shadow:0 0 0 2px #ef44444d;background:#ef44441a}[data-theme=dark] .batch-remove-btn{background:linear-gradient(135deg,#dc2626,#b91c1c)}[data-theme=dark] .batch-remove-btn:hover{background:linear-gradient(135deg,#b91c1c,#991b1b)}[data-theme=dark] .bulk-mode-toggle{background:var(--bg-secondary);border-color:var(--border-color);color:var(--text-secondary)}[data-theme=dark] .bulk-mode-toggle:hover{background:var(--bg-tertiary);border-color:var(--border-color)}[data-theme=dark] .bulk-mode-toggle.active{background:#ef444426;border-color:#ef4444;color:var(--ts-danger)}[data-theme=dark] .compare-checkbox .checkmark{background:var(--bg-tertiary);border-color:var(--border-color)}[data-theme=dark] .compare-checkbox:hover 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.asset-predictions-section{background:var(--bg-tertiary);border-top-color:var(--border-color)}[data-theme=dark] .asset-predictions-header{border-bottom-color:var(--border-color)}[data-theme=dark] .asset-predictions-header h4{color:var(--text-primary)}[data-theme=dark] .asset-predictions-placeholder{color:var(--text-tertiary)}[data-theme=dark] .prediction-item{background:var(--bg-secondary);border-color:var(--border-color)}[data-theme=dark] .prediction-label{color:var(--text-secondary)}[data-theme=dark] .prediction-value{color:var(--text-primary)}[data-theme=dark] .asset-expanded{background:var(--bg-tertiary);border-top:1px solid var(--border-color)}[data-theme=dark] .watchlist-layout,[data-theme=dark] .watchlist-grid{background:transparent}[data-theme=dark] .prediction-card{background:var(--bg-secondary);border:1px solid var(--border-color);border-radius:8px;margin-bottom:12px}[data-theme=dark] .prediction-header{background:var(--bg-tertiary);border-bottom:1px solid var(--border-color);padding:12px;border-radius:8px 8px 0 0}[data-theme=dark] .prediction-header:hover{background:var(--bg-hover)}[data-theme=dark] .prediction-title-row{color:var(--text-primary)}[data-theme=dark] .prediction-nct{color:var(--primary);font-weight:600}[data-theme=dark] .prediction-trial-title{color:var(--text-secondary)}[data-theme=dark] .confidence-badge{padding:4px 10px;border-radius:12px;font-size:12px;font-weight:600}[data-theme=dark] .confidence-badge.confidence-high{background:#10b98133;color:#6ee7b7}[data-theme=dark] .confidence-badge.confidence-medium{background:var(--ts-accent-bg);color:#fcd34d}[data-theme=dark] .confidence-badge.confidence-low{background:#ef444433;color:var(--ts-danger)}[data-theme=dark] .prediction-summary{padding:12px;color:var(--text-secondary);background:var(--bg-secondary)}[data-theme=dark] .prediction-summary strong{color:var(--text-primary)}[data-theme=dark] .prediction-details{padding:16px;background:var(--bg-secondary)}[data-theme=dark] .prediction-milestones{background:var(--bg-tertiary);border-radius:8px;padding:16px}[data-theme=dark] .prediction-milestones h5{color:var(--text-primary);margin-bottom:12px}[data-theme=dark] .timeline-visual{border-left:2px solid var(--border-color);padding-left:20px;margin-left:10px}[data-theme=dark] .milestone{position:relative;margin-bottom:16px}[data-theme=dark] .milestone-marker{position:absolute;left:-28px;background:var(--bg-secondary)}[data-theme=dark] .milestone-marker svg{color:var(--primary)}[data-theme=dark] .milestone-marker svg.confidence-high{color:#10b981}[data-theme=dark] .milestone-marker svg.confidence-medium{color:var(--ts-accent)}[data-theme=dark] .milestone-marker svg.confidence-low{color:#ef4444}[data-theme=dark] .milestone-content{background:var(--bg-secondary);border:1px solid var(--border-color);border-radius:6px;padding:10px 12px}[data-theme=dark] .milestone-header{display:flex;justify-content:space-between;align-items:center}[data-theme=dark] .milestone-name{color:var(--text-primary);font-weight:500}[data-theme=dark] .milestone-date{color:var(--text-secondary);font-size:13px}[data-theme=dark] .asset-news-list{background:transparent}[data-theme=dark] .asset-news-item{background:var(--bg-secondary);border:1px solid var(--border-color);border-radius:8px;padding:12px;margin-bottom:8px}[data-theme=dark] .asset-news-item:hover{background:var(--bg-hover);border-color:var(--primary)}[data-theme=dark] .news-item-header{display:flex;justify-content:space-between;margin-bottom:6px}[data-theme=dark] .news-item-source,[data-theme=dark] .news-item-date{color:var(--text-tertiary);font-size:12px}[data-theme=dark] .news-item-title{color:var(--primary);text-decoration:none;font-weight:500;display:block;margin-bottom:6px}[data-theme=dark] .news-item-title:hover{color:var(--secondary);text-decoration:underline}[data-theme=dark] .news-item-summary{color:var(--text-secondary);font-size:13px;line-height:1.4}[data-theme=dark] 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.trial-health-btn{background:linear-gradient(135deg,#10b98133,#14b8a633);border:1px solid rgba(16,185,129,.4);color:#6ee7b7}[data-theme=dark] .trial-health-btn:hover{background:linear-gradient(135deg,#10b9814d,#14b8a64d);border-color:#10b981;color:var(--ts-success)}[data-theme=dark] .trial-financial-btn{background:linear-gradient(135deg,#f59e0b33,#d9770633);border:1px solid var(--ts-accent-border);color:var(--ts-warning)}[data-theme=dark] .trial-financial-btn:hover{background:linear-gradient(135deg,#f59e0b4d,#d977064d);border-color:var(--ts-accent);color:#fcd34d}[data-theme=dark] .trial-risk-btn{background:linear-gradient(135deg,#ef444433,#dc262633);border:1px solid rgba(239,68,68,.4);color:var(--ts-danger)}[data-theme=dark] .trial-risk-btn:hover{background:linear-gradient(135deg,#ef44444d,#dc26264d);border-color:#ef4444;color:#fecaca}[data-theme=dark] .trial-competitive-btn{background:linear-gradient(135deg,#f5a52433,#6366f133);border:1px solid var(--ts-accent-border);color:var(--ts-accent)}[data-theme=dark] .trial-competitive-btn:hover{background:linear-gradient(135deg,#f5a5244d,#6366f14d);border-color:var(--accent);color:#ddd6fe}[data-theme=dark] .trial-approval-btn{background:linear-gradient(135deg,#3b82f633,#2563eb33);border:1px solid rgba(59,130,246,.4);color:#93c5fd}[data-theme=dark] .trial-approval-btn:hover{background:linear-gradient(135deg,#3b82f64d,#2563eb4d);border-color:#3b82f6;color:#bfdbfe}[data-theme=dark] .expand-icon{color:var(--text-tertiary)}[data-theme=dark] .expand-icon:hover{color:var(--text-primary)}[data-theme=dark] .refresh-news-btn,[data-theme=dark] .fetch-predictions-btn{background:var(--bg-secondary);border:1px solid var(--border-color);color:var(--text-secondary);padding:6px 12px;border-radius:6px;font-size:12px;display:flex;align-items:center;gap:6px;transition:all .2s ease}[data-theme=dark] .refresh-news-btn:hover,[data-theme=dark] 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.asset-suggestion{border-bottom-color:var(--border-color)}[data-theme=dark] .asset-suggestion:hover{background:var(--bg-hover)}[data-theme=dark] .asset-suggestion .asset-name{color:var(--text-primary)}[data-theme=dark] .asset-suggestion .asset-type,[data-theme=dark] .asset-suggestion .asset-count{color:var(--text-secondary)}[data-theme=dark] .asset-brands{color:#818cf8}[data-theme=dark] .asset-suggestion-group{border-bottom-color:var(--border-color)}[data-theme=dark] .expand-variants-btn{color:var(--text-secondary)}[data-theme=dark] .expand-variants-btn:hover{color:#818cf8}[data-theme=dark] .variant-list{background:var(--bg-secondary)}[data-theme=dark] .variant-item:hover{background:var(--bg-hover)}[data-theme=dark] .variant-name{color:var(--text-secondary)}[data-theme=dark] .modal-confirm{background:linear-gradient(135deg,var(--primary),var(--secondary))}[data-theme=dark] .executive-dashboard{background:transparent}[data-theme=dark] .dashboard-header h2,[data-theme=dark] 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